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Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation.

Molecular psychiatry - 1 Nov 2021

Fox Andrew S, Harris Ronald A, Rosso Laura Del, Raveendran Muthuswamy, Kamboj Shawn, Kinnally Erin L, Capitanio John P, Rogers Jeffrey

Abstract excerpt

An anxious or inhibited temperament (IT) early in life is a major risk factor for the later development of stress-related psychopathology. Starting in infancy, nonhuman primates, like humans, begin to reveal their temperament when exposed to novel situations. Here, in Study 1 we demonstrate this infant IT predicts adult behavior. Specifically, in over 600 monkeys, we found that individuals scored as inhibited...

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PMID: 34035480
DOI: 10.1038/s41380-021-01156-4
PMCID: PMC8613309

Genes

CTNNA2

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