Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation

Abstract excerpt

Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO creation by hydrophobic insertion into the ER membrane. Here, we found that the association of NS1 with the membrane can be facilitated by the electrostatic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV Research and Treatment
• Share to Malaria Research and Control
• Share to Mosquito-borne diseases and control