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Article

Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity.

Human cell - 1 Jul 2021

Sakiyama Masayuki, Matsuo Hirotaka, Toyoda Yu, Yonekura Yuiko, Ishikawa Takahiro, Nakayama Akiyoshi, Higashino Toshihide, Kawamura Yusuke, Fujimoto Norihiro, Shinomiya Nariyoshi, Satoh Takahiro

Abstract excerpt

Photosensitivity is a skin reaction disorder mediated by phototoxic and/or photoallergic mechanisms. The accumulation of porphyrins is generally considered to induce phototoxicity. ATP-binding cassette subfamily G member 2 (ABCG2) has been identified as a transporter of porphyrins and its common variants-p.Gln126Ter (rs72552713) and p.Gln141Lys (rs2231142)-reportedly decrease the function of porphyrin transport...

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Identifiers

PMID: 34009629
DOI: 10.1007/s13577-021-00534-y
PMCID: PMC8197704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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