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Article

Successful treatment of triple EGFR mutation T785A/L861Q/H297_E298 with afatinib.

Thoracic cancer - 1 Jul 2021

Longo Vito, Catino Annamaria, Montrone Michele, Pizzutilo Pamela, Pesola Francesco, Marech Ilaria, Capone Iolanda, Prelaj Arsela, Galetta Domenico

Abstract excerpt

Patients with non-small cell lung cancer (NSCLC) and uncommon epidermal growth factor receptor (EGFR) mutation are characterized by high heterogeneity, and globally considered to have a worse prognosis than patients with the two common mutations; exon 19 deletion, and exon 21 L858R. Nevertheless, some uncommon mutations do confer sensitivity to tyrosine kinase inhibitors (TKIs) which is comparable with common...

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Identifiers

PMID: 34008923
DOI: 10.1111/1759-7714.13953
PMCID: PMC8258364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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