Prospective high-throughput genome profiling of advanced cancers: results of the PERMED-01 clinical trial.

doi:10.1186/s13073-021-00897-9

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Article

Prospective high-throughput genome profiling of advanced cancers: results of the PERMED-01 clinical trial.

Genome medicine - 18 May 2021

Bertucci François, Gonçalves Anthony, Guille Arnaud, Adelaïde José, Garnier Séverine, Carbuccia Nadine, Billon Emilien, Finetti Pascal, Sfumato Patrick, Monneur Audrey, Pécheux Christophe, Khran Martin, Brunelle Serge, Mescam Lenaïg, Thomassin-Piana Jeanne, Poizat Flora, Charafe-Jauffret Emmanuelle, Turrini Olivier, Lambaudie Eric, Provansal Magali, Extra Jean-Marc, Madroszyk Anne, Gilabert Marine, Sabatier Renaud, Vicier Cécile, Mamessier Emilie, Chabannon Christian, Pakradouni Jihane, Viens Patrice, André Fabrice, Gravis Gwenaelle, Popovici Cornel, Birnbaum Daniel, Chaffanet Max

Abstract excerpt

BACKGROUND: The benefit of precision medicine based on relatively limited gene sets and often-archived samples remains unproven. PERMED-01 (NCT02342158) was a prospective monocentric clinical trial assessing, in adults with advanced solid cancer, the feasibility and impact of extensive molecular profiling applied to newly biopsied tumor sample and based on targeted NGS (t-NGS) of the largest gene panel to date...

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Identifiers

PMID: 34006291
DOI: 10.1186/s13073-021-00897-9
PMCID: PMC8132379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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