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Article

Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery.

Frontiers in immunology - 1 Jan 2021

Baumgaertner Petra, Sankar Martial, Herrera Fernanda, Benedetti Fabrizio, Barras David, Thierry Anne-Christine, Dangaj Denarda, Kandalaft Lana E, Coukos George, Xenarios Ioannis, Guex Nicolas, Harari Alexandre

Abstract excerpt

Data obtained with cytometry are increasingly complex and their interrogation impacts the type and quality of knowledge gained. Conventional supervised analyses are limited to pre-defined cell populations and do not exploit the full potential of data. Here, in the context of a clinical trial of cancer patients treated with radiotherapy, we performed longitudinal flow cytometry analyses to identify multiple...

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Identifiers

PMID: 33995353
DOI: 10.3389/fimmu.2021.633910
PMCID: PMC8119773

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