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Article

Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2021

Li Shuying, Zhao Yaling, Nie Min, Yang Yufan, Hao Ming, Mao Jiangfeng, Wu Xueyan

Abstract excerpt

A retrospective study was conducted to investigate the effect of gonadotropin or pulsatile gonadotropin-releasing hormone (GnRH) therapy on spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) patients with PROKR2 (prokineticin receptor 2) or FGFR1 (fibroblast growth factor receptor 1) mutations. Clinical features, gonadotropin levels, testicular volume (TV), and sperm concentration in response to...

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Identifiers

PMID: 33983622
DOI: 10.1007/s43032-021-00609-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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