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Article

Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families.

Neural plasticity - 1 Jan 2021

Mei Xueshuang, Zhou Yaqi, Amjad Muhammad, Yang Weiqiang, Zhu Rufei, Asif Muhammad, Hussain Hafiz Muhammad Jafar, Yang Tao, Iqbal Furhan, Hu Hongyi

Abstract excerpt

Background: Approximately 70% of congenital deafness is attributable to genetic causes. Incidence of congenital deafness is known to be higher in families with consanguineous marriage. In this study, we investigated the genetic causes in three consanguineous Pakistani families segregating with prelingual, severe-to-profound deafness. Results: Through targeted next-generation sequencing of 414 genes known to be...

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Identifiers

PMID: 33976695
DOI: 10.1155/2021/5528434
PMCID: PMC8084664

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