Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2.

doi:10.1371/journal.pbio.3001236

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Article

Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2.

PLoS biology - 1 May 2021

Vogels Chantal B F, Breban Mallery I, Ott Isabel M, Alpert Tara, Petrone Mary E, Watkins Anne E, Kalinich Chaney C, Earnest Rebecca, Rothman Jessica E, Goes de Jesus Jaqueline, Morales Claro Ingra, Magalhães Ferreira Giulia, Crispim Myuki A E, Singh Lavanya, Tegally Houriiyah, Anyaneji Ugochukwu J, Hodcroft Emma B, Mason Christopher E, Khullar Gaurav, Metti Jessica, Dudley Joel T, MacKay Matthew J, Nash Megan, Wang Jianhui, Liu Chen, Hui Pei, Murphy Steven, Neal Caleb, Laszlo Eva, Landry Marie L, Muyombwe Anthony, Downing Randy, Razeq Jafar, de Oliveira Tulio, Faria Nuno R, Sabino Ester C, Neher Richard A, Fauver Joseph R, Grubaugh Nathan D

Abstract excerpt

With the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants that may increase transmissibility and/or cause escape from immune responses, there is an urgent need for the targeted surveillance of circulating lineages. It was found that the B.1.1.7 (also 501Y.V1) variant, first detected in the United Kingdom, could be serendipitously detected by the Thermo Fisher TaqPath COVID-19 PCR...

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PMID: 33961632
DOI: 10.1371/journal.pbio.3001236
PMCID: PMC8133773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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