Article
Familial pseudohyperkalemia induces significantly higher levels of extracellular potassium in early storage of red cell concentrates without affecting other standard measures of quality: A case control and allele frequency study.
Transfusion - 1 Aug 2021
Meli Athinoula, McAndrew Margaret, Frary Amy, Rehnstrom Karola, Stevens-Hernandez Christian J, Flatt Joanna F, Griffiths Alexandra, Stefanucci Luca, Astle William, Anand Rekha, New Helen V, Bruce Lesley J, Cardigan Rebecca
Abstract excerpt
BACKGROUND: Familial pseudohyperkalemia (FP) is characterized by an increased rate of potassium leakage in refrigerated red cells and is associated with the minor allele of the single nucleotide polymorphism rs148211042 (R723Q) in the ABCB6 gene. The study aims were to obtain the minor allele frequencies of ABCB6 variants and to measure supernatant potassium accumulation, and other red cell storage parameters, in...
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