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Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4

6 May 2021

Abstract excerpt

Cancer-associated fibroblasts (CAFs) play an essential role in supporting cancer progression. However, the details and consequent effects in response to the communication between CAFs and angiogenesis remain largely uninvestigated, especially in anticancer drug treatments. We found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein...

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PMID: 33953165
DOI: 10.1038/s41420-021-00478-0

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