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Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead.

Cells - 27 Apr 2021

Lake Julie, Storm Catherine S, Makarious Mary B, Bandres-Ciga Sara

Abstract excerpt

Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of characteristic genetic and transcriptomic indicators for preclinical disease diagnosis, prognosis, or subtyping is...

Topics

Biomarkers
Humans
Multifactorial Inheritance
Mutation
Neurodegenerative Diseases
Transcriptome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33925602
DOI: 10.3390/cells10051030
PMCID: PMC8170880

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