Article
Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells.
International journal of molecular sciences - 23 Apr 2021
Tseng Wei-Che, Chen Chi-Yuan, Chern Ching-Yuh, Wang Chu-An, Lee Wen-Chih, Chi Ying-Chih, Cheng Shu-Fang, Kuo Yi-Tsen, Chiu Ya-Chen, Tseng Shih-Ting, Lin Pei-Ya, Liou Shou-Jhen, Li Yi-Chen, Chen Chin-Chuan
Abstract excerpt
BRCA mutation, one of the most common types of mutations in breast and ovarian cancer, has been suggested to be synthetically lethal with depletion of RAD52. Pharmacologically inhibiting RAD52 specifically eradicates BRCA-deficient cancer cells. In this study, we demonstrated that curcumin, a plant polyphenol, sensitizes BRCA2-deficient cells to CPT-11 by impairing RAD52 recombinase in MCF7 cells. More...
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