Article
Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 5 Oct 2021
Sumner Kelsey M, Freedman Elizabeth, Mangeni Judith N, Obala Andrew A, Abel Lucy, Edwards Jessie K, Emch Michael, Meshnick Steven R, Pence Brian W, Prudhomme-O'Meara Wendy, Taylor Steve M
Abstract excerpt
BACKGROUND: Repeated exposure to malaria infections could protect against symptomatic progression as people develop adaptive immunity to infections acquired over time. METHODS: We investigated how new, recurrent, and persistent Plasmodium falciparum infections were associated with the odds of developing symptomatic compared with asymptomatic malaria. Using a 14-month longitudinal cohort in Western Kenya, we used...
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