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Article

Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2

22 Apr 2021

Abstract excerpt

modeling analyses determined that G641D mutation in the methyltransferase (MT)-like domain of nsP2 is essential for its interaction with cytoplasmic Hsp90β chaperone. Our findings collectively support the potential application of radicicol as an anti-CHIKV agent. The detailed study of the underlying mechanism of action further contributes to our understanding of virus-host interactions for novel therapeutics...

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PMID: 33903104
DOI: 10.1128/aac.00135-21

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