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Article

TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer

9 Apr 2021

Abstract excerpt

The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC tumor suppressor and potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. The expression of TOX was lower in CRC than para-CRC. With the increase of tumor stage, TOX expression decreased, indicating the presence of TOX relates to...

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PMID: 33897695
DOI: 10.3389/fimmu.2021.647540

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