An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.

doi:10.1096/fj.202100113RR

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Article

An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2021

Vann Christopher G, Morton Robert W, Mobley Christopher B, Vechetti Ivan J, Ferguson Brian K, Haun Cody T, Osburn Shelby C, Sexton Casey L, Fox Carlton D, Romero Matthew A, Roberson Paul A, Oikawa Sara Y, McGlory Chris, Young Kaelin C, McCarthy John J, Phillips Stuart M, Roberts Michael D

Abstract excerpt

We examined the association between genotype and resistance training-induced changes (12 wk) in dual x-ray energy absorptiometry (DXA)-derived lean soft tissue mass (LSTM) as well as muscle fiber cross-sectional area (fCSA; vastus lateralis; n = 109; age = 22 ± 2 y, BMI = 24.7 ± 3.1 kg/m2 ). Over 315 000 genetic polymorphisms were interrogated from muscle using DNA microarrays. First, a targeted investigation was...

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PMID: 33891350
DOI: 10.1096/fj.202100113RR
PMCID: PMC8234740

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GLI3

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