Article
Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders.
Stem cell reports - 8 Jun 2021
Anderson Nickesha C, Chen Pin-Fang, Meganathan Kesavan, Afshar Saber Wardiya, Petersen Andrew J, Bhattacharyya Anita, Kroll Kristen L, Sahin Mustafa
Abstract excerpt
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilities (IDDs). However, issues related to variability and reproducibility have hindered translating preclinical findings into drug discovery. Here, we identify areas for...
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