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Article

Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD.

Hepatology communications - 1 Apr 2021

Wegermann Kara, Garrett Melanie E, Zheng Jiayin, Coviello Andrea, Moylan Cynthia A, Abdelmalek Manal F, Chow Shein-Chung, Guy Cynthia D, Diehl Anna Mae, Ashley-Koch Allison, Suzuki Ayako

Abstract excerpt

The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism-related single nucleotide polymorphisms (SNPs), whose effect on NAFLD fibrosis is significantly modified by sex and menopausal status. We performed a...

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Identifiers

PMID: 33860118
DOI: 10.1002/hep4.1668
PMCID: PMC8034580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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