Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients.

doi:10.1097/TP.0b013e3181ff4ff3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients.

Transplantation - 27 Dec 2010

Mifsud Nicole A, Nguyen Thi Hoang Oanh, Tait Brian D, Kotsimbos Tom C

Abstract excerpt

BACKGROUND: Cross-reactive antiviral memory T cells constitute a significant proportion of the alloresponse, potentially playing a pivotal role in adverse posttransplant outcomes in human leukocyte antigen (HLA)-mismatched allografts. We explored the longitudinal dynamics of cross-reactive HLA-B8-restricted Epstein-Barr virus-specific CD8+ T cells directed toward the EBNA3A epitope FLRGRAYGL (FLR) in lung...

Topics

B-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Line
Cohort Studies
Cross Reactions
DNA, Viral
Epstein-Barr Virus Infections
Genetic Variation
HLA-B Antigens
HLA-B44 Antigen
HLA-B8 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Herpesvirus 4, Human

Humans

Immunologic Memory

Isoantigens

Lung Transplantation

Receptors, Antigen, T-Cell

T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 21042237
DOI: 10.1097/TP.0b013e3181ff4ff3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients.PMID 21042237Read ↗

New tools to monitor the impact of viral infection on the alloreactive T‐cell repertoireSemantic proximity Read ↗

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.Semantic proximity Read ↗

Allo-HLA Cross-Reactivities of Cytomegalovirus-, Influenza-, and Varicella Zoster Virus–Specific Memory T Cells Are Shared by Different Healthy IndividualsSemantic proximity Read ↗

Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognitionSemantic proximity Read ↗

Changes in HCMV immune cell frequency and phenotype are associated with chronic lung allograft dysfunction.Semantic proximity Read ↗

Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosisSemantic proximity Read ↗

Allo-HLA reactivity of virus-specific memory T cells is commonSemantic proximity Read ↗

Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivitySemantic proximity Read ↗

Alloreactivity Across HLA Barriers Is Mediated by Both Naïve and Antigen-Experienced T CellsSemantic proximity Read ↗

Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction.Semantic proximity Read ↗

Distinct germinal center selection at local sites shapes memory B cell response to viral escape.Semantic proximity Read ↗

CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.