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Article

Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1.

The Journal of allergy and clinical immunology - 1 Sept 2021

Petersen Anders Ø, Jokinen Martta, Plichta Damian R, Liebisch Gerhard, Gronwald Wolfram, Dettmer Katja, Oefner Peter J, Vlamakis Hera, Chung Daniel C, Ranki Annamari, Xavier Ramnik J

Abstract excerpt

BACKGROUND: Gastrointestinal dysfunction is a frequent and disabling manifestation of autoimmune polyendocrine syndrome type 1 (APS-1), a rare monogenic multiorgan autoimmune disease caused by the loss of central AIRE-controlled immune tolerance. OBJECTIVES: This study aimed to understand the role of the gut microbiome in APS-1 symptoms and potentially alleviate common gastrointestinal symptoms by probiotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33819509
DOI: 10.1016/j.jaci.2021.03.025
PMCID: PMC8429070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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