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AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer

23 Mar 2021

Abstract excerpt

Autophagy is considered to be an important switch for facilitating normal to malignant cell transformation during colorectal cancer development. Consistent with other reports, we found that the membrane receptor Neuropilin1 (NRP1) is greatly upregulated in colon cancer cells that underwent autophagy upon glucose deprivation. However, the mechanism underlying NRP1 regulation of autophagy is unknown. We found that...

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PMID: 33758077
DOI: 10.1242/jcs.255273

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