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Article

Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.

Journal of biochemistry - 22 Sept 2021

Li Zhuang, Zhao Bo, Shi Yueru, Liang Yuqi, Qian Rui, Wan Youzhong

Abstract excerpt

SF3B1, an essential RNA splicing factor, is frequently mutated in various types of cancers, and the cancer-associated SF3B1 mutation causes aberrant RNA splicing. The aberrant splicing of several transcripts, including MAP3K7, promotes tumorigenesis. Here, we identify a premature termination codon in the aberrantly spliced transcript of MAP3K7. Treatment of HEK293T cells transfected with the K700E-mutated SF3B1...

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Identifiers

PMID: 33751071
DOI: 10.1093/jb/mvab023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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