Second Report of Chronic Granulomatous Disease in Jordan: Clinical and Genetic Description of 31 Patients From 21 Different Families, Including Families From Lybia and Iraq.

doi:10.3389/fimmu.2021.639226

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Second Report of Chronic Granulomatous Disease in Jordan: Clinical and Genetic Description of 31 Patients From 21 Different Families, Including Families From Lybia and Iraq.

Frontiers in immunology - 1 Jan 2021

Bakri Faris Ghalib, Mollin Michelle, Beaumel Sylvain, Vigne Bénédicte, Roux-Buisson Nathalie, Al-Wahadneh Adel Mohammed, Alzyoud Raed Mohammed, Hayajneh Wail Ahmad, Daoud Ammar Khaled, Shukair Mohammed Elian Abu, Karadshe Mansour Fuad, Sarhan Mahmoud Mohammad, Al-Ramahi Jamal Ahmad Wadi, Fauré Julien, Rendu John, Stasia Marie Jose

Abstract excerpt

Chronic granulomatous Disease (CGD) is a rare innate immunodeficiency disorder caused by mutations in one of the six genes (CYBA, CYBB, NCF1, NCF2, NCF4, and CYBC1/EROS) encoding the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase complex in phagocytes. In the Western population, the most prevalent form of CGD (about two-thirds of all cases) is the X-linked form (X-CGD) caused by...

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PMID: 33746979
DOI: 10.3389/fimmu.2021.639226
PMCID: PMC7973097

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