Article
Low dystrophin variability between muscles and stable expression over time in Becker muscular dystrophy using capillary Western immunoassay.
Scientific reports - 15 Mar 2021
Koeks Z, Janson A A, Beekman C, Signorelli M, van Duyvenvoorde H A, van den Bergen J C, Hooijmans M T, Alleman I, Hegeman I M, Verschuuren J J G M, V Deutekom J C, Spitali P, Datson N A, Niks E H
Abstract excerpt
Becker muscular dystrophy (BMD) is the milder allelic variant of Duchenne muscular dystrophy, with higher dystrophin levels. To anticipate on results of interventions targeting dystrophin expression it is important to know the natural variation of dystrophin expression between different muscles and over time. Dystrophin was quantified using capillary Western immunoassay (Wes) in the anterior tibial (TA) muscle of...
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