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Article

Heterogeneity of dystrophin expression in patients with Duchenne and Becker muscular dystrophy.

Acta neuropathologica - 1 Jan 1990

Nicholson L V, Johnson M A, Gardner-Medwin D, Bhattacharya S, Harris J B

Abstract excerpt

This report documents the results of an integrated biochemical and immunocytochemical investigation into the expression of dystrophin (the protein product of the Duchenne muscular dystrophy gene) in muscle biopsies from 226 patients. It is the first study in which dystrophin has been analysed on blots and on tissue sections in such a large number of patients using the same (monoclonal) antibody. The 140 patients...

Topics

Adolescent
Biopsy
Child
Child, Preschool
Dystrophin
Genetic Linkage
Humans
Immunoblotting
Immunohistochemistry
Muscle Proteins
Muscles
Muscular Dystrophies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuromuscular Diseases

Phenotype

X Chromosome

Source

Identifiers

PMID: 2205076
DOI: 10.1007/BF00294640

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2205076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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