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Article

Joint analysis of expression levels and histological images identifies genes associated with tissue morphology.

Nature communications - 11 Mar 2021

Ash Jordan T, Darnell Gregory, Munro Daniel, Engelhardt Barbara E

Abstract excerpt

Histopathological images are used to characterize complex phenotypes such as tumor stage. Our goal is to associate features of stained tissue images with high-dimensional genomic markers. We use convolutional autoencoders and sparse canonical correlation analysis (CCA) on paired histological images and bulk gene expression to identify subsets of genes whose expression levels in a tissue sample correlate with...

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Identifiers

PMID: 33707455
DOI: 10.1038/s41467-021-21727-x
PMCID: PMC7952575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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