Article
Impact of new myeloma agents on the transfusion laboratory.
Pathology - 1 Apr 2021
Jones Andrew D, Moayeri Morvarid, Nambiar Ashok
Abstract excerpt
Monoclonal antibody (mAb) therapy targeting CD38 and CD47 antigens expressed on cancer cells has transformed therapy options for patients with multiple myeloma as well as other haematological and non-haematological malignancies. While the on target effects of these new drugs highlight the promise of precision cancer therapeutics, the unintended, off target binding of drugs to red blood cells (RBCs) and platelets...
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