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Molecular and Functional Effects of Loss of Cytochrome c Oxidase Subunit 8A.

Biochemistry. Biokhimiia - 1 Jan 2021

Rotko Daria, Kudin Alexei P, Zsurka Gábor, Kulawiak Bogusz, Szewczyk Adam, Kunz Wolfram S

Abstract excerpt

In this work we studied molecular and functional effects of the loss of the smallest nuclear encoded subunit of cytochrome c oxidase COX8A in fibroblasts from a patient with a homozygous splice site mutation and in CRISPR/Cas9 genome-edited HEK293T cells. In both cellular model systems, between 20 to 30% of the residual enzymatic activity of cytochrome c oxidase (COX) was detectable. In immunoblots of BN-PAGE...

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PMID: 33705280
DOI: 10.1134/S0006297921010041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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