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Article

ADAM17 is an essential attachment factor for classical swine fever virus

8 Mar 2021

Abstract excerpt

Classical swine fever virus (CSFV) is an important pathogen in the swine industry. Virion attachment is mediated by envelope proteins Erns and E2, and E2 is indispensable. Using a pull-down assay with soluble E2 as the bait, we demonstrated that ADAM17, a disintegrin and metalloproteinase 17, is essential for CSFV entry. Loss of ADAM17 in a permissive cell line eliminated E2 binding and viral entry, but...

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PMID: 33684175
DOI: 10.1371/journal.ppat.1009393

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