Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation

17 Feb 2021

Abstract excerpt

Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY release from tumor tissue associates with metastatic disease. Here, we have shown that NPY stimulates NB cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Neuroblastoma Research and Treatments
Share to Neuropeptides and Animal Physiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33681186
DOI: 10.3389/fcell.2020.627090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA ActivationPMID 33681186Read ↗

Relevance of the Neuropeptide Y System in the Biology of Cancer ProgressionSemantic proximity Read ↗

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical OutcomeSemantic proximity Read ↗

A NOTCH3 Transcriptional Module Induces Cell Motility in NeuroblastomaSemantic proximity Read ↗

Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcomaSemantic proximity Read ↗

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.Semantic proximity Read ↗

The emerging role of class-3 semaphorins and their neuropilin receptors in oncologySemantic proximity Read ↗

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastomaSemantic proximity Read ↗

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPasesSemantic proximity Read ↗

Amphoterin as an extracellular regulator of cell motility: from discovery to diseaseSemantic proximity Read ↗

MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathwaySemantic proximity Read ↗

Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastomaSemantic proximity Read ↗

Neuropilin Functions as an Essential Cell Surface Receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.