Article
Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes.
Scientific reports - 3 Mar 2021
Chen Yung-Che, Tsai Ying-Huang, Wang Chin-Chou, Liu Shih-Feng, Chen Ting-Wen, Fang Wen-Feng, Lee Chiu-Ping, Hsu Po-Yuan, Chao Tung-Ying, Wu Chao-Chien, Wei Yu-Feng, Chang Huang-Chih, Tsen Chia-Cheng, Chang Yu-Ping, Lin Meng-Chih
Abstract excerpt
We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of 228 COPD patients were identified as ACO, which was independently associated with increased exacerbations. Microarray analysis identified 404 differentially methylated loci (DML) in ACO patients, and 6575 DML in those with rapid lung function...
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