Article
Cytomegalovirus-specific T-cell reconstitution following letermovir prophylaxis after hematopoietic cell transplantation.
Blood - 8 Jul 2021
Zamora Danniel, Duke Elizabeth R, Xie Hu, Edmison Bradley C, Akoto Brenda, Kiener Richard, Stevens-Ayers Terry, Wagner Ralf, Mielcarek Marco, Leisenring Wendy M, Jerome Keith R, Schiffer Joshua T, Finak Greg, De Rosa Stephen C, Boeckh Michael
Abstract excerpt
Decreased cytomegalovirus (CMV)-specific immunity after hematopoietic cell transplantation (HCT) is associated with late CMV reactivation and increased mortality. Whether letermovir prophylaxis-associated reduction in viral exposure influences CMV-specific immune reconstitution is unknown. In a prospective cohort of allogeneic HCT recipients who received letermovir, we compared polyfunctional CMV-specific T-cell...
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