Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies

Abstract excerpt

BACKGROUND: Early identification of pregnant women at risk for preeclampsia (PE) is important, as it will enable targeted interventions ahead of clinical manifestations. The quantitative analyses of plasma proteins feature prominently among molecular approaches used for risk prediction. However, derivation of protein signatures of sufficient predictive power has been challenging. The recent availability of...

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