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Article

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

1 Mar 2021

Abstract excerpt

SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced...

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PMID: 33649323
DOI: 10.1038/s41467-021-21634-1

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