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Article

USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1.

Gene - 1 Mar 2016

Tang Li-Juan, Li Yu, Liu Ying-Li, Wang Jian-Min, Liu Dian-Wu, Tian Qing-Bao

Abstract excerpt

Ubiquitin-specific protease 12 (USP12) plays a significant role in tumor cell apoptosis and cell cycle progression. However, the regulatory mechanism of USP12 in human cervical carcinoma HeLa cell growth is unknown. In this study, we showed that knockdown of USP12 effectively induced cell cycle arrest in HeLa cells and decreased BMI-1, c-Myc and cyclin D2 transcription levels. By contrast, unlike the inactive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26680102
DOI: 10.1016/j.gene.2015.12.006

Genes

USP12

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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