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Article

Validation of oral brushing as a non-invasive technique for the identification of feline oral squamous cell carcinoma by DNA methylation and TP53 mutation analysis.

Veterinary and comparative oncology - 1 Sept 2021

Renzi Andrea, Morandi Luca, Bellei Emma, Marconato Laura, Rigillo Antonella, Aralla Marina, Lenzi Jacopo, Bettini Giuliano, Tinto Debora, Sabattini Silvia

Abstract excerpt

Feline oral squamous cell carcinoma (FOSCC) is a frequent and progressively invasive tumour. Early lesions are difficult to recognize based on the sole clinical examination and may be misinterpreted as non-neoplastic. Mutations of TP53 and epigenetic alterations of specific genes are present in FOSCC and may be early detected. Aim of this prospective study was to investigate the DNA methylation pattern of a...

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PMID: 33624422
DOI: 10.1111/vco.12688

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