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Digital PCR for high sensitivity viral detection in false-negative SARS-CoV-2 patients

22 Feb 2021

Abstract excerpt

Patients requiring diagnostic testing for coronavirus disease 2019 (COVID-19) are routinely assessed by reverse-transcription quantitative polymerase chain reaction (RT-qPCR) amplification of Sars-CoV-2 virus RNA extracted from oro/nasopharyngeal swabs. Despite the good specificity of the assays certified for SARS-CoV-2 molecular detection, and a theoretical sensitivity of few viral gene copies per reaction, a...

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PMID: 33619321
DOI: 10.1038/s41598-021-83723-x

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