Article
Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Oct 2021
Lim Jia Lun, Ng Ebonne Yulin, Lim Shen-Yang, Tan Ai Huey, Abdul-Aziz Zariah, Ibrahim Khairul Azmi, Gopalai Aroma Agape, Tay Yi Wen, Vijayanathan Yuganthini, Toh Tzi Shin, Lim Soo Kun, Bee Ping-Chong, Puvanarajah Santhi Datuk, Viswanathan Shanthi, Looi Irene, Lim Thien Thien, Eow Gaik Bee, Cheah Wee Kooi, Tan Eng-King, Ahmad-Annuar Azlina
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have shown that variants in the 3-methylcrotonyl-CoA carboxylase (MCCC1)/lysosome-associated membrane protein 3 (LAMP3) loci (rs10513789, rs12637471, rs12493050) reduce the risk of Parkinson's disease (PD) in Caucasians, Chinese and Ashkenazi-Jews while the rs11248060 variant in the diacylglycerol kinase theta (DGKQ) gene increases the risk of PD in Caucasian and...