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Article

Novel Genetic Variants of PPARγ2 Promoter in Gestational Diabetes Mellitus and its Molecular Regulation in Adipogenesis.

Frontiers in endocrinology - 1 Jan 2020

Wu Ling, Song Yi, Zhang Yuan, Liang Bo, Deng Yan, Tang Tao, Ye Yan Chou, Hou Hong Ying, Wang Chi Chiu

Abstract excerpt

Peroxisome proliferator-activated receptor γ2 (PPARγ2) is a nuclear hormone receptor of ligand-dependent transcription factor with a key role in adipogenesis and insulin sensitization in diabetes mellitus. In this study, we investigated genetic variants in PPARγ2 promoter, its association with gestational diabetes mellitus (GDM), and its molecular regulation. PPARγ2 promoter and start codon (-2,091 to +82 bp)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 33551986
DOI: 10.3389/fendo.2020.499788
PMCID: PMC7862745

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