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Article

[Pharmacoresistance to psychotropic drugs in children and adolescents: Pharmacogenetic anomalies of cytochrome P450 2D6].

L'Encephale - 1 Jun 2021

David A, Fernandez A, Menard M-L, Dor E, Leali G, Maria F, Cruzel C, Askenazy F, Verstuyft C, Thümmler S

Abstract excerpt

OBJECTIVES: Some patients in child and adolescent psychiatry present resistance to psychotropic drugs, often resulting in polytherapy, an increased risk of adverse events, and more frequent and longer hospitalisation. Psychotropic drugs are mainly metabolised in the liver, in particular by the CYP2D6 subunit of cytochrome P450. Anomalies such as a duplication of the CYP2D6 gene related to an ultra-rapid...

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Source

Identifiers

PMID: 33551122
DOI: 10.1016/j.encep.2020.09.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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