Article
Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.
Orphanet journal of rare diseases - 4 Feb 2021
Reinert Marie-Christine, Pacheu-Grau David, Catarino Claudia B, Klopstock Thomas, Ohlenbusch Andreas, Schittkowski Michael, Wilichowski Ekkehard, Rehling Peter, Brockmann Knut
Abstract excerpt
BACKGROUND: Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder and characterized by acute or subacute painless visual loss. Environmental factors reported to trigger visual loss in LHON mutation carriers include smoking, heavy intake of alcohol, raised intraocular pressure, and some drugs, including several carbonic anhydrase inhibitors. The antiepileptic drug sulthiame (STM) is...
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