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Article

Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?

International journal of molecular sciences - 2 Feb 2021

Dommel Sebastian, Blüher Matthias

Abstract excerpt

The mechanisms of how obesity contributes to the development of cardio-metabolic diseases are not entirely understood. Obesity is frequently associated with adipose tissue dysfunction, characterized by, e.g., adipocyte hypertrophy, ectopic fat accumulation, immune cell infiltration, and the altered secretion of adipokines. Factors secreted from adipose tissue may induce and/or maintain a local and systemic...

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PMID: 33540898
DOI: 10.3390/ijms22031500
PMCID: PMC7867366

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