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Article

Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodies.

Internal medicine (Tokyo, Japan) - 15 Jun 2021

Tanemoto Masanobu, Hisahara Shin, Ikeda Kazuna, Yokokawa Kazuki, Manabe Tatsuo, Tsuda Reiko, Yamamoto Daisuke, Matsushita Takashi, Matsumura Akihiro, Suzuki Syuuichirou, Shimohama Shun

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) due to a fused in sarcoma (FUS) P525L mutation is characterized by a rapidly progressive course. Multifocal motor neuropathy (MMN) may resemble ALS in early stage and is associated with anti-ganglioside antibodies. A 38-year-old woman was admitted to our hospital because of progressive muscle weakness in the right limbs. She had mild mental retardation and minor deformities....

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Identifiers

PMID: 33518565
DOI: 10.2169/internalmedicine.6168-20
PMCID: PMC8263198

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