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Detection of colorectal cancer in urine using DNA methylation analysis

27 Jan 2021

Abstract excerpt

Colorectal cancer (CRC) is the second leading cause for cancer-related death globally. Clinically, there is an urgent need for non-invasive CRC detection. This study assessed the feasibility of CRC detection by analysis of tumor-derived methylated DNA fragments in urine. Urine samples, including both unfractioned and supernatant urine fractions, of 92 CRC patients and 63 healthy volunteers were analyzed for DNA...

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PMID: 33504902
DOI: 10.1038/s41598-021-81900-6

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