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Article

Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma.

Journal of neuro-oncology - 1 Mar 2021

Dono Antonio, Amsbaugh Mark, Martir Magda, Smilie Richard H, Riascos Roy F, Zhu Jay-Jiguang, Hsu Sigmund, Kim Dong H, Tandon Nitin, Ballester Leomar Y, Blanco Angel I, Esquenazi Yoshua

Abstract excerpt

INTRODUCTION: Despite aggressive treatment, glioblastoma invariably recurs. The optimal treatment for recurrent glioblastoma (rGBM) is not well defined. Stereotactic radiosurgery (SRS) for rGBM has demonstrated favorable outcomes for selected patients; however, its efficacy in molecular GBM subtypes is unknown. We sought to identify genetic alterations that predict response/outcomes from SRS in rGBM-IDH-wild-type...

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Brain Neoplasms
Glioblastoma
Mutation
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PTEN Phosphohydrolase

Salvage Therapy

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PMID: 33492602
DOI: 10.1007/s11060-020-03689-0
PMCID: PMC8354320

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