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Article

The impact of osimertinib' line on clonal evolution in EGFRm NSCLC through NGS-based liquid biopsy and overcoming strategies for resistance.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2021

Fuchs Vered, Roisman Laila, Kian Waleed, Daniel Levin, Dudnik Julia, Nechushtan Hovav, Goldstein Iris, Dvir Addie, Soussan-Gutman Lior, Grinberg Roxana, Gillis Roni, Peled Nir

Abstract excerpt

BACKGROUND: Resistance mechanisms following 1st line therapy with osimertinib in EGFR + NSCLC have become focus of investigation. This retrospective study aims to deepen the understanding and clarify possible mechanisms of osimertinib 1st line resistance in comparison to the 2nd line by examining NGS results of 30 patients who developed resistance to osimertinib. Furthermore, we followed clinical outcomes of...

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PMID: 33486418
DOI: 10.1016/j.lungcan.2020.12.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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