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Article

Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast.

Science (New York, N.Y.) - 22 Jan 2021

Boocock James, Sadhu Meru J, Durvasula Arun, Bloom Joshua S, Kruglyak Leonid

Abstract excerpt

Metabolic pathways differ across species but are expected to be similar within a species. We discovered two functional, incompatible versions of the galactose pathway in Saccharomyces cerevisiae We identified a three-locus genetic interaction for growth in galactose, and used precisely engineered alleles to show that it arises from variation in the galactose utilization genes GAL2, GAL1/10/7, and...

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Identifiers

PMID: 33479156
DOI: 10.1126/science.aba0542
PMCID: PMC8384573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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