Article
Correlations between Resistance Classifications Based on Penicillin-Binding Protein Genotypes and Antimicrobial Susceptibility Test Results of Haemophilus influenzae.
Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology - 25 Dec 2020
Funashima Yumiko, Nagasawa Yoshihiro, Narita Taeko, Hanaiwa Hiroki, Nagasawa Zenzo
Abstract excerpt
There are several problems associated with antimicrobial susceptibility testing (AST) of Haemophilus influenzae. β-Lactamase-negative ampicillin-resistant H. influenzae (BLNAR) isolates with minimum inhibitory concentration (MIC) of ampicillin (ABPC) <4 mg/l will be classified as susceptible according to the MIC breakpoint of the CLSI M100 criteria, in spite of harboring penicillin-binding protein (PBP) mutations...
Topics
- Ampicillin
- Anti-Bacterial Agents
- Anti-Infective Agents
- Drug Resistance, Bacterial
- Genotype
- Haemophilus influenzae
- Japan
- Microbial Sensitivity Tests
- Penicillin-Binding Proteins
- beta-Lactamases