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Article

Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish.

Autophagy - 1 Nov 2021

Ping Xiyuan, Liang Jiancheng, Shi Kexin, Bao Jing, Wu Jing, Yu Xiaoning, Tang Xiajing, Zou Jian, Shentu Xingchao

Abstract excerpt

Macroautophagy/autophagy is known to be important for intracellular quality control in the lens. GJA8 is a major gap junction protein in vertebrate lenses. Mutations in GJA8 cause cataracts in humans. The well-known cataractogenesis mechanism is that mutated GJA8 leads to abnormal assembly of gap junctions, resulting in defects in intercellular communication among lens cells. In this study, we observed that...

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Identifiers

PMID: 33472493
DOI: 10.1080/15548627.2021.1872188
PMCID: PMC8632074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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